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USP Purified Water for Pharma: What the Validation Package Must Include

Meera Iyer

Meera Iyer

Pharma Water Systems Specialist, Navbharat Water

USP Purified Water for Pharma: What the Validation Package Must Include

USP Purified Water (PW) is the most common pharmaceutical water grade — used for formulation, equipment washing, and as feedwater for WFI systems. Meeting USP <1231> and ICH Q7 requirements demands rigorous validation.

USP Purified Water Standards

ParameterUSP Limit
Conductivity≤1.3 µS/cm at 25°C
TOC≤500 ppb
Microbial≤100 CFU/mL (action limit)
EndotoxinsNot specified for PW (WFI: <0.25 EU/mL)

Required Validation Documents

  • DQ (Design Qualification): System design vs. URS compliance
  • IQ (Installation Qualification): Equipment installed per design
  • OQ (Operational Qualification): System operates per design limits
  • PQ (Performance Qualification): 3-phase, 12-month monitoring program

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